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Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1

Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear that in live cell models caspase-1 activation occurs in the process of its cel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Shamaa, Obada R., Mitra, Srabani, Gavrilin, Mikhail A., Wewers, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657934/
https://ncbi.nlm.nih.gov/pubmed/26599267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142203
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