Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

The PI3K/Akt/mTORC1 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance, and metastasis. One molecule regulated by this pathway is GSK-3β. GSK-3β is phosphorylated by Akt on S9, which leads to its inactivation; however, GSK-3β also can regulate the act...

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Bibliografiske detaljer
Main Authors: Sokolosky, Melissa, Chappell, William H, Stadelman, Kristin, Abrams, Stephen L, Davis, Nicole M, Steelman, Linda S, McCubrey, James A
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979918/
https://ncbi.nlm.nih.gov/pubmed/24407515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27728
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