Inhibition of mTOR-Dependent Autophagy Sensitizes Leukemic Cells to Cytarabine-Induced Apoptotic Death

The present study investigated the role of autophagy, a cellular self-digestion process, in the cytotoxicity of antileukemic drug cytarabine towards human leukemic cell lines (REH, HL-60, MOLT-4) and peripheral blood mononuclear cells from leukemic patients. The induction of autophagy was confirmed...

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Detalhes bibliográficos
Main Authors: Bosnjak, Mihajlo, Ristic, Biljana, Arsikin, Katarina, Mircic, Aleksandar, Suzin-Zivkovic, Violeta, Perovic, Vladimir, Bogdanovic, Andrija, Paunovic, Verica, Markovic, Ivanka, Bumbasirevic, Vladimir, Trajkovic, Vladimir, Harhaji-Trajkovic, Ljubica
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979773/
https://ncbi.nlm.nih.gov/pubmed/24714637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094374
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