Extension of the Germinal Center Stage of B-cell Development Promotes Autoantibodies in BXD2 Mice

OBJECTIVE: Regulator of G-protein Signaling (RGS) proteins inhibit chemokine signaling by desensitizing G-protein coupled receptor signals. The mechanisms by which RGS13 promotes the generation of pathogenic autoantibodies in germinal centers (GC) were determined using BXD2-Rgs13(−/−) mice. METHODS:...

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Main Authors: Wang, John H., New, James S., Xie, Shutao, Yang, PingAr, Wu, Qi, Li, Jun, Luo, Bao, Ding, Yanna, Druey, Kirk M., Hsu, Hui-Chen, Mountz, John D
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979745/
https://ncbi.nlm.nih.gov/pubmed/23818250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38059
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