Calcium Regulates Molecular Interactions of Otoferlin with Soluble NSF Attachment Protein Receptor (SNARE) Proteins Required for Hair Cell Exocytosis

Mutations in otoferlin, a C2 domain-containing ferlin family protein, cause non-syndromic hearing loss in humans (DFNB9 deafness). Furthermore, transmitter secretion of cochlear inner hair cells is compromised in mice lacking otoferlin. In the present study, we show that the C2F domain of otoferlin...

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Bibliografiske detaljer
Main Authors: Ramakrishnan, Neeliyath A., Drescher, Marian J., Morley, Barbara J., Kelley, Philip M., Drescher, Dennis G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979417/
https://ncbi.nlm.nih.gov/pubmed/24478316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480533
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