Calcium Regulates Molecular Interactions of Otoferlin with Soluble NSF Attachment Protein Receptor (SNARE) Proteins Required for Hair Cell Exocytosis

Mutations in otoferlin, a C2 domain-containing ferlin family protein, cause non-syndromic hearing loss in humans (DFNB9 deafness). Furthermore, transmitter secretion of cochlear inner hair cells is compromised in mice lacking otoferlin. In the present study, we show that the C2F domain of otoferlin...

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Detalhes bibliográficos
Main Authors: Ramakrishnan, Neeliyath A., Drescher, Marian J., Morley, Barbara J., Kelley, Philip M., Drescher, Dennis G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979417/
https://ncbi.nlm.nih.gov/pubmed/24478316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480533
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