The Perforin Pore Facilitates the Delivery of Cationic Cargos

Cytotoxic lymphocytes eliminate virally infected or neoplastic cells through the action of cytotoxic proteases (granzymes). The pore-forming protein perforin is essential for delivery of granzymes into the cytoplasm of target cells; however the mechanism of this delivery is incompletely understood....

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Autori principali: Stewart, Sarah E., Kondos, Stephanie C., Matthews, Antony Y., D'Angelo, Michael E., Dunstone, Michelle A., Whisstock, James C., Trapani, Joseph A., Bird, Phillip I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979413/
https://ncbi.nlm.nih.gov/pubmed/24558045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544890
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