Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding

Perforin is an essential component in the cytotoxic lymphocyte-mediated cell death pathway. The traditional view holds that perforin monomers assemble into pores in the target cell membrane via a calcium-dependent process and facilitate translocation of cytotoxic proteases into the cytoplasm to indu...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Stewart, Sarah E., Bird, Catherina H., Tabor, Rico F., D'Angelo, Michael E., Piantavigna, Stefania, Whisstock, James C., Trapani, Joseph A., Martin, Lisandra L., Bird, Phillip I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692234/
https://ncbi.nlm.nih.gov/pubmed/26542805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683078
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