Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo

Despite progress in identifying molecular drivers of cancer, it has been difficult to translate this knowledge into new therapies, because many of the causal proteins cannot be inhibited by conventional small molecule therapeutics. RNA interference (RNAi), which uses small RNAs to inhibit gene expre...

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Autori principali: Dudek, Henryk, Wong, Darren H, Arvan, Rokhand, Shah, Anee, Wortham, Kathleen, Ying, Bo, Diwanji, Rohan, Zhou, Wei, Holmes, Benjamin, Yang, Hailin, Cyr, Wendy A, Zhou, Yi, Shah, Aalok, Farkiwala, Ruchir, Lee, Michael, Li, Yiting, Rettig, Garrett R, Collingwood, Michael A, Basu, Sujit K, Behlke, Mark A, Brown, Bob D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978813/
https://ncbi.nlm.nih.gov/pubmed/24089139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.233
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