Evidence for impaired amyloid β clearance in Alzheimer's disease

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the accumulation of extracellular plaques and intracellular tangles. Recent studies support the hypothesis that the accumulation of amyloid beta (Aβ) peptide within the brain arises from an imbalance of the producti...

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Bibliographic Details
Main Authors: Wildsmith, Kristin R, Holley, Monica, Savage, Julie C, Skerrett, Rebecca, Landreth, Gary E
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978761/
https://ncbi.nlm.nih.gov/pubmed/23849219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt187
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