Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

In Alzheimer’s disease soluble amyloid beta (sAβ) causes synaptic dysfunction and neuronal loss. Receptors involved in clearance of sAβ are not known. Here we use shRNA screening and identify the scavenger receptor Scara1 as a receptor for sAβ expressed on myeloid cells. To determine the role of Sca...

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Main Authors: Frenkel, Dan, Wilkinson, Kim, Zhao, Lingzhi, Hickman, Suzanne E., Means, Terry K., Puckett, Lindsey, Farfara, Dorit, Kingery, Nathan D., Weiner, Howard L., El Khoury, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702268/
https://ncbi.nlm.nih.gov/pubmed/23799536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3030
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