Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

In Alzheimer’s disease soluble amyloid beta (sAβ) causes synaptic dysfunction and neuronal loss. Receptors involved in clearance of sAβ are not known. Here we use shRNA screening and identify the scavenger receptor Scara1 as a receptor for sAβ expressed on myeloid cells. To determine the role of Sca...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Frenkel, Dan, Wilkinson, Kim, Zhao, Lingzhi, Hickman, Suzanne E., Means, Terry K., Puckett, Lindsey, Farfara, Dorit, Kingery, Nathan D., Weiner, Howard L., El Khoury, Joseph
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702268/
https://ncbi.nlm.nih.gov/pubmed/23799536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3030
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares