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Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the measurement of the somatic mutations that drive cancer development. However, the resulting sequencing datasets are large and complex, obscuring the clinically important mutations in a background of errors, noise,...

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Autors principals: Raphael, Benjamin J, Dobson, Jason R, Oesper, Layla, Vandin, Fabio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978567/
https://ncbi.nlm.nih.gov/pubmed/24479672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm524
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