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Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Cytolytic activity by CD8(+) cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is progressively dampened during chronic infection, yet the environmental cues and molecular pathways that influence imm...

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Bibliografske podrobnosti
Main Authors: Doedens, Andrew L, Phan, Anthony T, Stradner, Martin H, Fujimoto, Jessica K, Nguyen, Jessica V, Yang, Edward, Johnson, Randall S, Goldrath, Ananda W
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977965/
https://ncbi.nlm.nih.gov/pubmed/24076634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2714
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