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Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
Cytolytic activity by CD8(+) cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is progressively dampened during chronic infection, yet the environmental cues and molecular pathways that influence imm...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977965/ https://ncbi.nlm.nih.gov/pubmed/24076634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2714 |
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