Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8(+) T cells

Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates in patients with solid tumors underscore remaining challenges in realizing the potential of this cellular immunotherapy approach. Promoting CD8(+) T cell adaptation to tissue residency represents...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Liikanen, Ilkka, Lauhan, Colette, Quon, Sara, Omilusik, Kyla, Phan, Anthony T., Bartrolí, Laura Barceló, Ferry, Amir, Goulding, John, Chen, Joyce, Scott-Browne, James P., Yustein, Jason T., Scharping, Nicole E., Witherden, Deborah A., Goldrath, Ananda W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011896/
https://ncbi.nlm.nih.gov/pubmed/33792560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143729
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