Glutaredoxin-1 Attenuates S-Glutathionylation of the Death Receptor Fas and Decreases Resolution of Pseudomonas aeruginosa Pneumonia

Rationale: The death receptor Fas is critical for bacterial clearance and survival of mice after Pseudomonas aeruginosa infection. Objectives: Fas ligand (FasL)–induced apoptosis is augmented by S-glutathionylation of Fas (Fas-SSG), which can be reversed by glutaredoxin-1 (Grx1). Therefore, the obje...

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Autors principals: Anathy, Vikas, Aesif, Scott W., Hoffman, Sidra M., Bement, Jenna L., Guala, Amy S., Lahue, Karolyn G., Leclair, Laurie W., Suratt, Benjamin T., Cool, Carlyne D., Wargo, Matthew J., Janssen-Heininger, Yvonne M. W.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977722/
https://ncbi.nlm.nih.gov/pubmed/24325366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201310-1905OC
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