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RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling. Current evidence indicates that RSPO–LGR4 functions to e...

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Bibliographic Details
Main Authors: Carmon, Kendra S., Gong, Xing, Yi, Jing, Thomas, Anthony, Liu, Qingyun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977305/
https://ncbi.nlm.nih.gov/pubmed/24639526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323106111
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