Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

The four R-spondins (RSPO1-4) and their three related receptors LGR4, 5 and 6 (LGR4-6) have emerged as a major ligand-receptor system with critical roles in development and stem cell survival through modulation of Wnt signaling. Recurrent, gain-of-expression gene fusions of RSPO2 (to EIF3E) and RSPO...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Gong, Xing, Yi, Jing, Carmon, Kendra S., Crumbley, Christine A., Xiong, Wei, Thomas, Anthony, Fan, Xuejun, Guo, Shan, An, Zhiqiang, Chang, Jeffrey T., Liu, Qingyun J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476959/
https://ncbi.nlm.nih.gov/pubmed/25531322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.417
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