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Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids
Few mutations attenuate Mycobacterium tuberculosis (Mtb) more profoundly than deletion of its isocitrate lyases (ICLs). However, the basis for this attenuation remains incompletely defined. Mtb’s ICLs are catalytically bifunctional isocitrate and methylisocitrate lyases required for growth on even a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977286/ https://ncbi.nlm.nih.gov/pubmed/24639517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400390111 |
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