Cargando...

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids

Few mutations attenuate Mycobacterium tuberculosis (Mtb) more profoundly than deletion of its isocitrate lyases (ICLs). However, the basis for this attenuation remains incompletely defined. Mtb’s ICLs are catalytically bifunctional isocitrate and methylisocitrate lyases required for growth on even a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Eoh, Hyungjin, Rhee, Kyu Y.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977286/
https://ncbi.nlm.nih.gov/pubmed/24639517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400390111
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!