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Programmable bacteria detect and record an environmental signal in the mammalian gut

The mammalian gut is a dynamic community of symbiotic microbes that interact with the host to impact health, disease, and metabolism. We constructed engineered bacteria that survive in the mammalian gut and sense, remember, and report on their experiences. Based on previous genetic memory systems, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kotula, Jonathan W., Kerns, S. Jordan, Shaket, Lev A., Siraj, Layla, Collins, James J., Way, Jeffrey C., Silver, Pamela A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977281/
https://ncbi.nlm.nih.gov/pubmed/24639514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321321111
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