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Multiple cells-of-origin of mutant K-Ras–induced mouse lung adenocarcinoma

Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)–induced lung adenocarcinoma. To shed light on this issue, we have used technology that enables us to conditionally target K-RasG12D expression in Surfactant Protein C (SPC)(+) alveolar type 2 cells and in Clara cell antigen 10...

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Detalhes bibliográficos
Main Authors: Sutherland, Kate D., Song, Ji-Ying, Kwon, Min Chul, Proost, Natalie, Zevenhoven, John, Berns, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977239/
https://ncbi.nlm.nih.gov/pubmed/24586047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319963111
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