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Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor

The aim of this work was to develop a fast-dissolving film formulation containing EFdA for potential use as a topical vaginal microbicide for prevention of HIV sexual transmission. Solid state compatibility approaches were used to screen commonly used polymers for formulation development. Factorial...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Parniak, Michael A., Sarafianos, Stefan G., Cost, Marilyn R., Rohan, Lisa C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976986/
https://ncbi.nlm.nih.gov/pubmed/24333452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2013.11.056
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