Vaginal microbicide film combinations of two reverse transcriptase inhibitors, EFdA and CSIC, for the prevention of HIV-1 sexual transmission

PURPOSE: EFdA is a potent nucleoside reverse transcriptase inhibitor (NRTI) with activity against a wide spectrum of wild-type and drug resistant HIV-1 variants. CSIC is a tight-binding non-nucleoside reverse transcriptase inhibitor (NNRTI) with demonstrated anti-HIV properties important for use in...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Zhang, Wei, Hu, Minlu, Shi, Yuan, Gong, Tiantian, Dezzutti, Charlene S., Moncla, Bernard, Sarafianos, Stefan G., Parniak, Michael A., Rohan, Lisa C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529374/
https://ncbi.nlm.nih.gov/pubmed/25794967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1678-2
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