Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

KRas has recently been shown to be activated by monoubiquitination (mUb). Similar to oncogenic mutations, mUb of Ras at position 147 activates Ras by causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism by which mUb impairs GAP-mediated downregulation of Ras, w...

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Bibliographic Details
Main Authors: Hobbs, G Aaron, Gunawardena, Harsha P, Baker, Rachael, Campbell, Sharon L
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Commentary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976977/
https://ncbi.nlm.nih.gov/pubmed/24030601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.26270
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