Nalaganje...

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

KRas has recently been shown to be activated by monoubiquitination (mUb). Similar to oncogenic mutations, mUb of Ras at position 147 activates Ras by causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism by which mUb impairs GAP-mediated downregulation of Ras, w...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Hobbs, G Aaron, Gunawardena, Harsha P, Baker, Rachael, Campbell, Sharon L
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976977/
https://ncbi.nlm.nih.gov/pubmed/24030601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.26270
Oznake: Označite
Brez oznak, prvi označite!