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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function
KRas has recently been shown to be activated by monoubiquitination (mUb). Similar to oncogenic mutations, mUb of Ras at position 147 activates Ras by causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism by which mUb impairs GAP-mediated downregulation of Ras, w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976977/ https://ncbi.nlm.nih.gov/pubmed/24030601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.26270 |
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