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Reversible overexpression of BACE1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice
BACKGROUND: Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by BACE1 releases a secreted N-terminal fragment (Nrg1-ntf(β)), which can bind to a cognate ErbB receptor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976896/ https://ncbi.nlm.nih.gov/pubmed/24210810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.09.026 |
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