Fixing frataxin: ‘ironing out’ the metabolic defect in Friedreich's ataxia

The metabolically active and redox-active mitochondrion appears to play a major role in the cellular metabolism of the transition metal, iron. Frataxin, a mitochondrial matrix protein, has been identified as playing a key role in the iron metabolism of this organelle due to its iron-binding properti...

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Bibliografiske detaljer
Main Authors: Anzovino, A, Lane, D J R, Huang, M L-H, Richardson, D R
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976629/
https://ncbi.nlm.nih.gov/pubmed/24138602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12470
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