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Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

Friedreich ataxia (FA) is a progressive neurodegenerative disease caused by expansion of a trinucleotide repeat within the first intron of the gene that encodes frataxin. In our study, we investigated the regulation of frataxin expression by iron and demonstrated that frataxin mRNA levels decrease s...

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Détails bibliographiques
Auteurs principaux: Li, Kuanyu, Besse, Edward K., Ha, Dung, Kovtunovych, Gennadiy, Rouault, Tracey A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2465796/
https://ncbi.nlm.nih.gov/pubmed/18424449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn127
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