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Mechanism of frataxin “bypass” in human iron–sulfur cluster biosynthesis with implications for Friedreich's ataxia

In humans, mitochondrial iron–sulfur cluster biosynthesis is an essential biochemical process mediated by the assembly complex consisting of cysteine desulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron–sulfur cluster assembly scaffold protein (ISCU2). The protein fratax...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Das, Deepika, Patra, Shachin, Bridwell-Rabb, Jennifer, Barondeau, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556584/
https://ncbi.nlm.nih.gov/pubmed/30975898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007716
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