Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment of KB cells at 37 degrees C rapidly induces a 50% reduction in epidermal growth factor (EGF) binding that is maximal by 30 min. EGF binding activity returns to the original value by 1 hr and remains constant for 2 hr thereafter. Using a polyclon...

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Autores principales: Beguinot, L, Hanover, J A, Ito, S, Richert, N D, Willingham, M C, Pastan, I
Formato: Artigo
Lenguaje:Inglês
Publicado: 1985
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC397648/
https://ncbi.nlm.nih.gov/pubmed/2859591
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