Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment of KB cells at 37 degrees C rapidly induces a 50% reduction in epidermal growth factor (EGF) binding that is maximal by 30 min. EGF binding activity returns to the original value by 1 hr and remains constant for 2 hr thereafter. Using a polyclon...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Beguinot, L, Hanover, J A, Ito, S, Richert, N D, Willingham, M C, Pastan, I
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1985
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397648/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2859591/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.9.2774
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