Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

Fluorescent derivatives of insulin and epidermal growth factor bound to 3T3 mouse fibroblasts are mobile on the cell surface, with similar diffusion coefficients, D approximately (3--5) x 10(-10) cm2/sec at 23 degrees C. Increasing the temperature to 37 degrees C results in rapid receptor immobiliza...

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Detalhes bibliográficos
Main Authors: Schlessinger, J, Shechter, Y, Cuatrecasas, P, Willingham, M C, Pastan, I
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC392961/
https://ncbi.nlm.nih.gov/pubmed/214784
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