Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from the literature supporting this assoc...

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Bibliographische Detailangaben
Hauptverfasser: Crews, K R, Gaedigk, A, Dunnenberger, H M, Leeder, J S, Klein, T E, Caudle, K E, Haidar, C E, Shen, D D, Callaghan, J T, Sadhasivam, S, Prows, C A, Kharasch, E D, Skaar, T C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
CPIC Update
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975212/
https://ncbi.nlm.nih.gov/pubmed/24458010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.254
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