The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting...

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Bibliographische Detailangaben
Hauptverfasser: Ramsey, L B, Johnson, S G, Caudle, K E, Haidar, C E, Voora, D, Wilke, R A, Maxwell, W D, McLeod, H L, Krauss, R M, Roden, D M, Feng, Q, Cooper-DeHoff, R M, Gong, L, Klein, T E, Wadelius, M, Niemi, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
CPIC Update
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169720/
https://ncbi.nlm.nih.gov/pubmed/24918167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.125
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