Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotype and select opioid therapy

Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone and methadone). Polymorphisms in CYP2D6 have been studied for an association with the clinical effect and safety of these drugs. Other gen...

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Publicat a:Clin Pharmacol Ther
Autors principals: Crews, Kristine R., Monte, Andrew A., Huddart, Rachel, Caudle, Kelly E., Kharasch, Evan D., Gaedigk, Andrea, Dunnenberger, Henry M., Leeder, J. Steven, Callaghan, John T., Samer, Caroline Flora, Klein, Teri E., Haidar, Cyrine E., Van Driest, Sara L., Ruano, Gualberto, Sangkuhl, Katrin, Cavallari, Larisa H., Müller, Daniel J., Prows, Cynthia A., Nagy, Mohamed, Somogyi, Andrew A., Skaar, Todd C.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249478/
https://ncbi.nlm.nih.gov/pubmed/33387367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2149
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