Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants

Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine are demethylated by CYP2C19 to pharmacologically active metaboli...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hicks, J K, Swen, J J, Thorn, C F, Sangkuhl, K, Kharasch, E D, Ellingrod, V L, Skaar, T C, Müller, D J, Gaedigk, A, Stingl, J C
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
CPIC Guidelines
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689226/
https://ncbi.nlm.nih.gov/pubmed/23486447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.2
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