Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants

Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine are demethylated by CYP2C19 to pharmacologically active metaboli...

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Detalhes bibliográficos
Main Authors: Hicks, J K, Swen, J J, Thorn, C F, Sangkuhl, K, Kharasch, E D, Ellingrod, V L, Skaar, T C, Müller, D J, Gaedigk, A, Stingl, J C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
CPIC Guidelines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689226/
https://ncbi.nlm.nih.gov/pubmed/23486447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.2
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