Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors

Inhibition of cyclooxygenase (COX) 2, which is associated with >40% of breast cancers, decreases the risk of tumorigenesis and breast cancer recurrence. To study the role of COX-2 in breast cancer, we engineered mice that lack selectively mammary epithelial cell (MEC) COX-2 (COX-2 KO(MEC)). Compa...

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Main Authors: Markosyan, Nune, Chen, Edward P., Ndong, Victoire N., Yao, Yubing, Sterner, Christopher J., Chodosh, Lewis A., Lawson, John A., FitzGerald, Garret A., Smyth, Emer M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Cancer Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975167/
https://ncbi.nlm.nih.gov/pubmed/21771729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr134
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