Mammary Carcinoma Cell Derived Cyclooxygenase 2 Suppresses Tumor Immune Surveillance by Enhancing Intratumoral Immune Checkpoint Activity

INTRODUCTION: Systemic inhibition of the inflammatory enzyme cyclooxygenase (COX) 2 decreases the risk of breast cancer and its recurrence. However, the biology of COX-2 in the multicellular tumor microenvironment is poorly defined. METHODS: Mammary tumor onset and multiplicity were examined in ErbB...

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Détails bibliographiques
Auteurs principaux: Markosyan, Nune, Chen, Edward P, Evans, Rebecca A, Ndong, Victoire, Vonderheide, Robert H, Smyth, Emer M
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979159/
https://ncbi.nlm.nih.gov/pubmed/24004819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3469
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