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The immune revolution: a case for priming, not checkpoint
Most tumors are unresponsive to immune checkpoint blockade, especially if deep immunosuppression in the tumor develops prior to and prevents T cell immunosurveillance. Failed or frustrated T-cell priming often needs repair before successful sensitization to PD-1/PD-L1 blockade. CD40 activation plays...
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| Publicado no: | Cancer Cell |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898647/ https://ncbi.nlm.nih.gov/pubmed/29634944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.03.008 |
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