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Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients.

We have studied 42 homozygous beta-thalassemia patients from Algeria and 34 sickle cell anemia patients from Senegal and Benin, determining the relationship between haplotypes, Hb F, and G gamma-globin/A gamma-globin ratios. Populations selected have a high frequency of haplotype homozygotes because...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Labie, D, Pagnier, J, Lapoumeroulie, C, Rouabhi, F, Dunda-Belkhodja, O, Chardin, P, Beldjord, C, Wajcman, H, Fabry, M E, Nagel, R L
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1985
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397502/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2580306/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.7.2111
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