Sickle gene. Its origin and diffusion from West Africa.

Linked DNA polymorphisms can be used to study the evolution of structural gene mutations. Both the beta S-(beta 6Glu leads to Val) and beta C-(beta 6Glu leads to Lys) genes are common in West Africa. We have analyzed their linkage to a polymorphic Hpa 1 site appearing 3' to the beta-globin gene locu...

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Publié dans:	J Clin Invest
Auteurs principaux:	Mears, J G, Lachman, H M, Cabannes, R, Amegnizin, K P, Labie, D, Nagel, R L
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1981
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6268660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110294
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