Sickle gene. Its origin and diffusion from West Africa.

Linked DNA polymorphisms can be used to study the evolution of structural gene mutations. Both the beta S-(beta 6Glu leads to Val) and beta C-(beta 6Glu leads to Lys) genes are common in West Africa. We have analyzed their linkage to a polymorphic Hpa 1 site appearing 3' to the beta-globin gene...

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Bibliographic Details
Main Authors: Mears, J G, Lachman, H M, Cabannes, R, Amegnizin, K P, Labie, D, Nagel, R L
Format: Artigo
Language:Inglês
Published: 1981
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC370840/
https://ncbi.nlm.nih.gov/pubmed/6268660
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