A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Cyclic nucleotide-modulated ion channels play crucial roles in signal transduction in eukaryotes. The molecular mechanism by which ligand binding leads to channel opening remains poorly understood, due in part to the lack of a robust method for preparing sufficient amounts of purified, stable protei...

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Bibliographic Details
Main Authors: McCoy, Jason G., Rusinova, Radda, Kim, Dorothy M., Kowal, Julia, Banerjee, Sourabh, Jaramillo Cartagena, Alexis, Thompson, Ameer N., Kolmakova-Partensky, Ludmila, Stahlberg, Henning, Andersen, Olaf S., Nimigean, Crina M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975005/
https://ncbi.nlm.nih.gov/pubmed/24515111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543389
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