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Efficient Parvovirus Replication Requires CRL4(Cdt2)-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA
Infection by the autonomous parvovirus minute virus of mice (MVM) induces a vigorous DNA damage response in host cells which it utilizes for its efficient replication. Although p53 remains activated, p21 protein levels remain low throughout the course of infection. We show here that efficient MVM re...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974872/ https://ncbi.nlm.nih.gov/pubmed/24699724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004055 |
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