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Efficient Parvovirus Replication Requires CRL4(Cdt2)-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA

Infection by the autonomous parvovirus minute virus of mice (MVM) induces a vigorous DNA damage response in host cells which it utilizes for its efficient replication. Although p53 remains activated, p21 protein levels remain low throughout the course of infection. We show here that efficient MVM re...

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Bibliografiske detaljer
Main Authors: Adeyemi, Richard O., Fuller, Matthew S., Pintel, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974872/
https://ncbi.nlm.nih.gov/pubmed/24699724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004055
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