A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis

Chronic tuberculosis in an immunocompetent host is a consequence of the delicately balanced growth of Mycobacterium tuberculosis (Mtb) in the face of host defense mechanisms. We identify an Mtb enzyme (Tdmh(Mtb)) that hydrolyzes the mycobacterial glycolipid trehalose dimycolate and plays a critical...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yang, Yong, Kulka, Kathleen, Montelaro, Ronald C., Reinhart, Todd A., Sissons, James, Aderem, Alan, Ojha, Anil K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974621/
https://ncbi.nlm.nih.gov/pubmed/24528862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.008
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