A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis

Chronic tuberculosis in an immunocompetent host is a consequence of the delicately balanced growth of Mycobacterium tuberculosis (Mtb) in the face of host defense mechanisms. We identify an Mtb enzyme (Tdmh(Mtb)) that hydrolyzes the mycobacterial glycolipid trehalose dimycolate and plays a critical...

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Bibliografiske detaljer
Main Authors: Yang, Yong, Kulka, Kathleen, Montelaro, Ronald C., Reinhart, Todd A., Sissons, James, Aderem, Alan, Ojha, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974621/
https://ncbi.nlm.nih.gov/pubmed/24528862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.008
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