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Enzymatic Hydrolysis of Trehalose Dimycolate Releases Free Mycolic Acids during Mycobacterial Growth in Biofilms

Mycobacterial species, like other microbes, spontaneously form multicellular drug-tolerant biofilms when grown in vitro in detergent-free liquid media. The structure of Mycobacterium tuberculosis biofilms is formed through genetically programmed pathways and is built upon a large abundance of novel...

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Main Authors: Ojha, Anil K., Trivelli, Xavier, Guerardel, Yann, Kremer, Laurent, Hatfull, Graham F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878501/
https://ncbi.nlm.nih.gov/pubmed/20375425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112813
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